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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 497-508 doi: 10.1007/s11684-017-0572-1

Abstract:

Viral infections cause at least 10%–15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.

Keywords： genome-editing tools     tumorigenic virus     delivery method     off-target effect     virus-related carcinoma    

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Effect of heat transfer coefficient of steam turbine rotor on thermal stress field under off-design condition

Jie GUO,Danmei XIE,Hengliang ZHANG,Wei JIANG,Yan ZHOU

Frontiers in Energy 2016, Volume 10, Issue 1,   Pages 57-64 doi: 10.1007/s11708-015-0385-3

Abstract: The precise calculation of temperature and thermal stress field of steam turbine rotor under off-design

Keywords： steam turbine     rotor     thermal stress     heat transfer coefficient     empirical formula    

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Advanced purification and comprehensive utilization of yellow phosphorous off gas

Ping NING,Xiangyu WANG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 2,   Pages 181-189 doi: 10.1007/s11783-014-0698-1

Abstract: Without appropriate purification and removal, this off gas has potential to cause severe pollution problemsPurified yellow phosphorous off gas can be beneficially reused as a raw material in chemical productionIn this paper, the significance of purification and reutilization of yellow phosphorous off gas are exploredprocesses, and main characteristics of the technologies for purification and reuse of yellow phosphorus offcomprehensive reutilization can be an effective solution for heavy pollution resulting from yellow phosphorous off

Keywords： yellow phosphorous off gas     purification     comprehensive utilization    

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Typical off-design analytical performances of internal combustion engine cogeneration

Xiaohong HE, Ruixian CAI

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 184-192 doi: 10.1007/s11708-009-0007-z

Abstract: Based on experimental data, typical off-design characteristic curves with corresponding formulas of internalrecovery steam generator (HRSG) and influence of ambient pressure on combined heat and power (CHP) system, off-design

Keywords： internal combustion engine (ICE)     cogeneration     heat recovery steam generator (HRSG)     off-design     superheated    

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Quantification of emission variability for off-road equipment in China based on real-world measurements

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1455-x

Abstract:

• Emissions from 53 in-use diesel-fueled off-road equipment were measured

Keywords： Off-road equipment     Portable emission measurement system (PEMS)     Real-world emissions     Diesel engine    

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Construction Technology of Off-Site Precast Concrete Buildings

Ting Gong,Jian Yang,Hao Hu,Feng Xu

Frontiers of Engineering Management 2015, Volume 2, Issue 2,   Pages 122-124 doi: 10.15302/J-FEM-2015039

Abstract: A comparison between traditional on-site and modern off-site construction methods has been conducted.

Keywords： off-site construction     precast concrete     modular construction     construction management     building information    

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Development and application of an off-site maintenance system in the petrochemical industry

Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING

Frontiers of Engineering Management 2017, Volume 4, Issue 2,   Pages 111-126 doi: 10.15302/J-FEM-2017027

Abstract: and exposure to hazards during on-site operations and thereby reduce the probability of accidents, off-site

Keywords： on-site maintenance     petrochemical industry     safety     off-site maintenance system    

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Trace analysis of off-flavor/odor compounds in water using liquid-liquid microextraction coupled with

Jian LU,Paul S. WILLS,P. CHRIS WILSON

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3,   Pages 477-481 doi: 10.1007/s11783-015-0820-z

Abstract: A rapid, inexpensive and laboratory friendly method was developed for analysis of off-flavor/odor compoundsOff-flavor/odor compounds included geosmin, 2-methylisoborneol (MIB), 2-isobutyl-3-methyoxypyrazine (

Keywords： off-flavor/odor compounds     liquid-liquid microextraction     gas chromatography-tandem mass spectrometry    

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Can energy storage make off-grid photovoltaic hydrogen production system more economical?

Frontiers of Engineering Management   Pages 672-694 doi: 10.1007/s42524-022-0245-x

Abstract: Thus, the installation of energy-storage equipment in a PVEH system is a complex trade-off problem.

Keywords： hydrogen     off-grid photovoltaic     energy storage     LCOH     engineering economics    

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glandshave shown that multiple types of pituitary hormone receptors are widely expressed in non-classical targetgland-derived hormone exhibits a wide range of nonconventional biological effects in these non-classical targetnon-classical organs were summarized, defined by the novel concept of an “atypical pituitary hormone–targetThe continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic hormone     prolactin    

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A systematic approach to ON-OFF event detection and clustering analysis of non-intrusive appliance load

Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP

Frontiers in Energy 2015, Volume 9, Issue 2,   Pages 231-237 doi: 10.1007/s11708-015-0358-6

Abstract: In this paper, a systematic approach to ON-OFF event detection and clustering analysis for NIALM wereThe event detection algorithm is to determine the switching of ON and OFF status of electrical appliancesAfter event detection, the events detected were paired into ON-OFF pairing appliances.The results from the ON-OFF pairing algorithm were further clustered in groups utilizing the -meansof the time duration an electrical appliance is turned ON through combination of event detection, ON-OFF

Keywords： non-intrusive appliance load monitoring     event detection     goodness-of-fit (GOF)     K-means clustering     ON-OFF    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract:  Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 11,   Pages 985-994 doi: 10.1631/FITEE.1500149

Abstract: To address the problem of maneuvering target tracking, where the target trajectory has prolonged smoothCompared with conventional variable rate models, the proposed model does not need any prior knowledge of target

Keywords： Maneuvering target tracking     Prolonged smooth regions     Variable rate model     Maneuver detection    

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Removal of multicomponent VOCs in off-gases from an oil refining wastewater treatment plant by a compost-based

Dan WU, Chunyan ZHANG, Li HAO, Changjun GENG, Xie QUAN,

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 4,   Pages 483-491 doi: 10.1007/s11783-009-0144-y

Abstract: of the performance and feasibility of removing multicomponent volatile organic compounds (VOCs) in off-gasesThe results demonstrated that multicomponent VOCs in off-gases from the oil refining wastewater treatment

Keywords： biodegradation     volatile organic compounds (VOCs)     biofiltration     biofilter    

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Title Author Date Type Operation

Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Journal Article

Effect of heat transfer coefficient of steam turbine rotor on thermal stress field under off-design condition

Jie GUO,Danmei XIE,Hengliang ZHANG,Wei JIANG,Yan ZHOU

Journal Article

Advanced purification and comprehensive utilization of yellow phosphorous off gas

Ping NING,Xiangyu WANG

Journal Article

Typical off-design analytical performances of internal combustion engine cogeneration

Xiaohong HE, Ruixian CAI

Journal Article

Quantification of emission variability for off-road equipment in China based on real-world measurements

Journal Article

Construction Technology of Off-Site Precast Concrete Buildings

Ting Gong,Jian Yang,Hao Hu,Feng Xu

Journal Article

Development and application of an off-site maintenance system in the petrochemical industry

Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING

Journal Article

Trace analysis of off-flavor/odor compounds in water using liquid-liquid microextraction coupled with

Jian LU,Paul S. WILLS,P. CHRIS WILSON

Journal Article

Can energy storage make off-grid photovoltaic hydrogen production system more economical?

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

Atypical pituitary hormone–target tissue axis

Journal Article

A systematic approach to ON-OFF event detection and clustering analysis of non-intrusive appliance load

Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

Journal Article

Removal of multicomponent VOCs in off-gases from an oil refining wastewater treatment plant by a compost-based

Dan WU, Chunyan ZHANG, Li HAO, Changjun GENG, Xie QUAN,

Journal Article